Search Clinical Trials
Sponsor Condition of Interest |
---|
Ipatasertib and Docetaxel in Metastatic NSCLC Patients Who Have Failed 1st Line Immunotherapy
Jun Zhang, MD, PhD
NSCLC Stage IV
NSCLC Stage IIIB
For metastatic/advanced NSCLC patients who do not have targetable mutations, either
immunotherapy targeting the programmed death-1 and its ligand (PD-1/L1) pathway alone or in
combination with platinum doublet chemotherapy is now a standard of care. However, still
about half... expand
For metastatic/advanced NSCLC patients who do not have targetable mutations, either immunotherapy targeting the programmed death-1 and its ligand (PD-1/L1) pathway alone or in combination with platinum doublet chemotherapy is now a standard of care. However, still about half of the patients do not benefit due to treatment resistance. It is therefore critically important to find novel therapies and combinations to benefit patients who have failed or are intolerant to 1st line immunotherapy. This study hypothesizes that ipatasertib in combination with taxane (e.g. docetaxel) can be an effective strategy. Ipatasertib is a novel adenosine triphosphate (ATP)-competitive inhibitor that has demonstrated robust and selective targeting of protein kinase B (PKB, also known as AKT) in cancer patients. Importantly, evidence from preclinical studies has demonstrated that AKT inhibitors (e.g. ipatasertib) can enhance the therapeutic effect of chemotherapy as well as immunotherapy via modulating Phosphatidylinositol 3-kinase (PI3'K)-AKT activity. Type: Interventional Start Date: Sep 2021 |
Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide
Alliance Foundation Trials, LLC.
Metastatic Prostate Cancer
Prostate Cancer Metastatic
Prostate Cancer
Castrate Resistant Prostate Cancer
This is a prospective, randomized, open-label phase II study comparing cognitive outcomes
between men with non-metastatic and metastatic castration-resistant prostate cancer (mCRPC or
M0CRPC) treated with darolutamide or enzalutamide. Approximately 132 patients will be
enrolled.... expand
This is a prospective, randomized, open-label phase II study comparing cognitive outcomes between men with non-metastatic and metastatic castration-resistant prostate cancer (mCRPC or M0CRPC) treated with darolutamide or enzalutamide. Approximately 132 patients will be enrolled. Eligible patients will be randomized in a 1:1 fashion to treatment with enzalutamide 160 mg orally daily or darolutamide 600 mg orally twice daily, in combination with standard LHRH agonist based treatment. Cognitive assessments will be performed using modules from Cambridge Neuropsychological Test Automated Battery (CANTAB) an internationally recognized software for assessing cognitive function and impairment. Type: Interventional Start Date: Aug 2021 |
Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel)...
National Cancer Institute (NCI)
Anatomic Stage IV Breast Cancer AJCC v8
Metastatic HER2-Negative Breast Carcinoma
Metastatic Malignant Neoplasm in the Bone
This phase II trial studies how well radium-223 dichloride and paclitaxel work in treating
patients with advanced breast cancer that has spread to the bones. Radium-223 dichloride is a
radioactive drug that behaves in a similar way to calcium and collects in cancer that has... expand
This phase II trial studies how well radium-223 dichloride and paclitaxel work in treating patients with advanced breast cancer that has spread to the bones. Radium-223 dichloride is a radioactive drug that behaves in a similar way to calcium and collects in cancer that has spread to the bones (bone metastases). The radioactive particles in radium-223 dichloride act on bone metastases, killing the tumor cells and reducing the pain that they can cause. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving radium-223 dichloride and paclitaxel may work better in treating patients with metastatic breast cancer compared to paclitaxel alone. Type: Interventional Start Date: Aug 2020 |
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
University of Kansas Medical Center
Hypertension
Cardiovascular Diseases
The main purpose of research is to examine and understanding the development of hypertension
in obese adults with insulin resistance. Findings from our studies will identify unique
mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the
excessively... expand
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance. Findings from our studies will identify unique mechanisms that can be targeted to limit increases in vascular dysfunction and reduce the excessively high prevalence of hypertension and risk for cardiovascular disease (CVD). This study is testing the health of the blood vessels and the activity of the nerves that control the blood vessels in adults with insulin resistance. The extent to which ascorbic acid (Vitamin C) improves the function of the blood vessels will be determined. The primary outcome is blood pressure, which is the result of blood vessel health and activity of the nerves, and the reduction in blood pressure that is observed with ascorbic acid. Type: Interventional Start Date: Jun 2021 |
Citadel Embolization Device Study
Stryker Neurovascular
Unruptured Wide-neck Aneurysms
The purpose of this study is to gather safety and effectiveness data on Stryker
Neurovascular's Next Generation Target Detachable Coil (hereafter referred to as the Citadel
Embolization Device), when used with Target Detachable Coils, in the treatment of wide-neck
intracranial... expand
The purpose of this study is to gather safety and effectiveness data on Stryker Neurovascular's Next Generation Target Detachable Coil (hereafter referred to as the Citadel Embolization Device), when used with Target Detachable Coils, in the treatment of wide-neck intracranial aneurysms. Type: Interventional Start Date: Jul 2019 |
OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study
Bioventus LLC
Lumbar Spine Disease
Lumbar Spondylolisthesis
Lumbar Spine Instability
Lumbar Spondylosis
Degenerative Disc Disease
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone
Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in
skeletally mature patients qualified for 2-lumbar interbody fusion (LIF) by means of an
intra-patient... expand
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar interbody fusion (LIF) by means of an intra-patient control model. Type: Interventional Start Date: May 2022 |
Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases
SWOG Cancer Research Network
Anatomic Stage IV Breast Cancer AJCC v8
Invasive Breast Carcinoma
Metastatic HER2 Negative Breast Carcinoma
Metastatic Malignant Neoplasm in the Brain
Prognostic Stage IV Breast Cancer AJCC v8
This phase II trial studies the effect of sacituzumab govitecan in treating patients with
HER2-negative breast cancer that has spread to the brain (brain metastases). Sacituzumab
govitecan is a monoclonal antibody, called sacituzumab, linked to a chemotherapy drug, called... expand
This phase II trial studies the effect of sacituzumab govitecan in treating patients with HER2-negative breast cancer that has spread to the brain (brain metastases). Sacituzumab govitecan is a monoclonal antibody, called sacituzumab, linked to a chemotherapy drug, called govitecan. Sacituzumab is a form of targeted therapy because it attaches to specific molecules on the surface of cancer cells, known as Trop-2 receptors, and delivers govitecan to kill them. Giving sacituzumab govitecan may shrink the cancer in the brain and/or extend the time until the cancer gets worse. Type: Interventional Start Date: Jun 2021 |
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic...
SWOG Cancer Research Network
Castration Levels of Testosterone
Metastatic Prostatic Adenocarcinoma
Stage IV Prostate Cancer AJCC v8
Stage IVA Prostate Cancer AJCC v8
Stage IVB Prostate Cancer AJCC v8
This phase III trial studies how well standard systemic therapy with or without definitive
treatment (prostate removal surgery or radiation therapy) works in treating participants with
prostate cancer that has spread to other places in the body. Addition of prostate removal... expand
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading. Type: Interventional Start Date: Sep 2018 |
Enfortumab Vedotin in Previously Treated Locally Advanced or Metastatic Pancreatic Cancer (EPIC)
University of Kansas Medical Center
Pancreatic Ductal Adenocarcinoma
Pancreas Adenocarcinoma
Pancreas Cancer
A Phase II Open-Label Study of Enfortumab Vedotin in Patients with Previously Treated Locally
Advanced, Recurrent, or Metastatic Pancreatic Adenocarcinoma (EPIC)
expand
A Phase II Open-Label Study of Enfortumab Vedotin in Patients with Previously Treated Locally Advanced, Recurrent, or Metastatic Pancreatic Adenocarcinoma (EPIC) Type: Interventional Start Date: Jun 2023 |
Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19):...
Ansun Biopharma, Inc.
Lower Respiratory Tract Infection
Parainfluenza
Immunocompromised
COVID-19
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza
infection.
It also contains a sub-study to enroll patients with severe COVID-19.
expand
This study will seek to enroll immunocompromised patients with Lower Tract parainfluenza infection. It also contains a sub-study to enroll patients with severe COVID-19. Type: Interventional Start Date: May 2019 |
Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study
ECOG-ACRIN Cancer Research Group
Anal Basaloid Carcinoma
Anal Canal Cloacogenic Carcinoma
Anal Canal Squamous Cell Carcinoma
Anal Margin Squamous Cell Carcinoma
Stage I Anal Cancer AJCC v8
This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation)
therapy works in comparison to standard-dose chemoradiation in treating patients with
early-stage anal cancer. Drugs used in chemotherapy, such as mitomycin, fluorouracil, and
capecitabine,... expand
This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation) therapy works in comparison to standard-dose chemoradiation in treating patients with early-stage anal cancer. Drugs used in chemotherapy, such as mitomycin, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. This study may help doctors find out if lower-dose chemoradiation is as effective and has fewer side effects than standard-dose chemoradiation, which is the usual approach for treatment of this cancer type. Type: Interventional Start Date: Jan 2020 |
Impact of E-cigarette Nicotine Concentration on Compensation
University of Kansas Medical Center
Smoking Cessation
The study will be the first to assess the impact of nicotine concentration on compensatory
puffing (total inhaled volume), nicotine delivery, and switch patterns (percent exclusive EC,
dual cig-EC, and cig only users) with an explicit focus on AA and White smokers.
expand
The study will be the first to assess the impact of nicotine concentration on compensatory puffing (total inhaled volume), nicotine delivery, and switch patterns (percent exclusive EC, dual cig-EC, and cig only users) with an explicit focus on AA and White smokers. Type: Interventional Start Date: Feb 2023 |
Rural Engagement in TelemedTeam for Options in Obesity Treatment Solutions
University of Kansas Medical Center
Obesity
Obesity, Morbid
The purpose of this study is to compare two methods for managing obesity in rural primary
care patients. The first method includes quarterly 1:1 meetings with the participant and
their primary care provider and the second includes a group lifestyle intervention over Zoom
paired... expand
The purpose of this study is to compare two methods for managing obesity in rural primary care patients. The first method includes quarterly 1:1 meetings with the participant and their primary care provider and the second includes a group lifestyle intervention over Zoom paired with quarterly team meetings with the participant, their primary care provider and their lifestyle coach, the coach joining via Zoom. Investigators will evaluate which method is best at helping participants lose weight over 18 months. Type: Interventional Start Date: Mar 2023 |
Alpelisib And Sacituzumab Govitecan For Treatment Of Breast Cancer
University of Kansas Medical Center
Breast Cancer
This study evaluates the safety and efficacy of sacituzumab govitecan plus alpelisib for
treatment of metastatic or locally recurrent HER2-negative breast cancer.
expand
This study evaluates the safety and efficacy of sacituzumab govitecan plus alpelisib for treatment of metastatic or locally recurrent HER2-negative breast cancer. Type: Interventional Start Date: Mar 2022 |
Whole Egg Intake and Choline Concentration in the Aging Brain
University of Kansas Medical Center
Alzheimer Disease
By doing this study, researchers hope to learn to see if there is relationship between whole
egg consumption and brain choline status. Additionally, researchers also plan to see if there
is a relationship between brain choline status and cognition.
expand
By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status. Additionally, researchers also plan to see if there is a relationship between brain choline status and cognition. Type: Observational Start Date: Jun 2021 |
Brain Responses to Contextual Influences on Drinking Decisions
University of Kansas Medical Center
Alcohol Drinking
This study is using functional magnetic resonance imaging (fMRI) to examine brain activity
associated with making decisions about drinking alcohol in everyday situations, some of which
may involve important activities happening the next day. The secondary aims are to determine... expand
This study is using functional magnetic resonance imaging (fMRI) to examine brain activity associated with making decisions about drinking alcohol in everyday situations, some of which may involve important activities happening the next day. The secondary aims are to determine whether severity of alcohol-related problems is related to brain activity and alcohol choices and to examine how different areas of the brain interact in connected networks. Type: Interventional Start Date: Feb 2023 |
Post Operative Delirium Study
University of Kansas Medical Center
Delirium
Post-operative delirium happens when patients wake up from anesthesia. Patients experiencing
post-operative delirium are very confused, not being able to think or function "normally".
These patients are hard to take care of and they tend to have more dementia as they age
compared... expand
Post-operative delirium happens when patients wake up from anesthesia. Patients experiencing post-operative delirium are very confused, not being able to think or function "normally". These patients are hard to take care of and they tend to have more dementia as they age compared to patients who don't experience post-operative delirium. Intranasal insulin has been shown to reverse confusion associated with Alzheimer's disease (humans) and AIDS (mice). Intranasal insulin has been safely administered to 1092 patients in 38 different studies. There were no cases of clinically low blood sugar and a few cases of mild nasal irritation that happened also with salt water when the subjects received multiple intranasal doses. No one has tried to reverse post-operative delirium with intranasal insulin. The delirium associated with Alzheimer's Disease and AIDS have very similar symptoms and what happens in the brain is very similar also. The investigators intent is to administer intranasal insulin to patients exhibiting post-operative delirium in order to reverse the symptoms because the investigators think that the three disease states are closely related and intranasal insulin has had some success in reversing the delirium in the other two disease states. Type: Interventional Start Date: Feb 2021 |
Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry
University of Kansas Medical Center
Breast Cancer
Hereditary Breast and Ovarian Cancer
PROGECT is a registry for patients with Triple Negative breast cancer (TNBC) or patients who
have an identified germline mutations (such as a mutation on the BRCA1 or BRCA2 genes).
expand
PROGECT is a registry for patients with Triple Negative breast cancer (TNBC) or patients who have an identified germline mutations (such as a mutation on the BRCA1 or BRCA2 genes). Type: Observational [Patient Registry] Start Date: Mar 2011 |
Changing Talk Online Training (CHATO) National Trial
University of Kansas Medical Center
Dementia
Alzheimer Disease
Communication
The National Plan to Address Alzheimer's disease has identified education of dementia care
providers as a top priority to address the need for quality care for the population of
persons with dementia that will triple in the next 30 years. This study will test new online
interactive... expand
The National Plan to Address Alzheimer's disease has identified education of dementia care providers as a top priority to address the need for quality care for the population of persons with dementia that will triple in the next 30 years. This study will test new online interactive training for nursing home staff that improves staff communication and also reduces behavioral symptoms of persons with dementia that they care for. Innovative approaches to reach care providers are essential to achieve implementation of evidence-based practices to improve care. Type: Interventional Start Date: Apr 2021 |
The SLEEPR Study: SLEep Effects on Post-stroke Rehabilitation
State University of New York - Upstate Medical University
Stroke
Sleep Wake Disorders
Rehabilitation
Recovery of Function
Sleep is critical for health and quality of life; however, little is known about the
prevalence or impact of non obstructive sleep apnea (non-OSA) sleep disorders in people with
stroke. The proposed study aims to characterize the proportion of people with stroke that
have... expand
Sleep is critical for health and quality of life; however, little is known about the prevalence or impact of non obstructive sleep apnea (non-OSA) sleep disorders in people with stroke. The proposed study aims to characterize the proportion of people with stroke that have non-OSA sleep disorders and their impact on recovery of activities of daily living, functional mobility, and participation along the continuum of recovery in people with stroke. Type: Observational Start Date: Mar 2021 |
Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and...
University of Kansas Medical Center
Acute Myeloid Leukemia
Chronic Myeloid Leukemia
Acute Lymphoblastic Leukemia
Myelodysplastic Syndromes
Gamma delta T-cells are part of the innate immune system with the ability to recognize
malignant cells and kill them. This study uses gamma delta T-cells to maximize the anti-tumor
response and minimize graft versus host disease (GVHD) in leukemic and myelodysplastic
patients... expand
Gamma delta T-cells are part of the innate immune system with the ability to recognize malignant cells and kill them. This study uses gamma delta T-cells to maximize the anti-tumor response and minimize graft versus host disease (GVHD) in leukemic and myelodysplastic patients who have had a partially mismatched bone marrow transplant (haploidentical). Type: Interventional Start Date: Jan 2020 |
International Weight Control Registry
Tufts University
Weight Loss
Overweight
Obesity
The IWCR is a global scientific study aimed at better understanding the opportunities and
barriers for reducing the prevalence of obesity by collecting information from people who
have experience with weight management in their everyday lives. The investigators seek to
gather... expand
The IWCR is a global scientific study aimed at better understanding the opportunities and barriers for reducing the prevalence of obesity by collecting information from people who have experience with weight management in their everyday lives. The investigators seek to gather information on a wide range of weight management experiences, ranging from weight loss and weight loss maintenance to weight gain and inability to lose weight. Type: Observational [Patient Registry] Start Date: Dec 2020 |
Itraconazole to Prevent Recurrent Barrett's Esophagus
University of Kansas Medical Center
Barrett Oesophagitis With Dysplasia
Recurrent Barrett's esophagus (BE) that occurs at the rate of 12.4%/year is the Achilles heel
of the endoscopic treatment of high-risk BE. Over time, after eradication, BE ultimately
recurs in as many as 30-50% of the patients putting them at risk for esophageal
adenocarcinoma... expand
Recurrent Barrett's esophagus (BE) that occurs at the rate of 12.4%/year is the Achilles heel of the endoscopic treatment of high-risk BE. Over time, after eradication, BE ultimately recurs in as many as 30-50% of the patients putting them at risk for esophageal adenocarcinoma (EAC), thereby undoing the benefits of an effective initial therapy. Also, recurrences need retreatments that increase costs and complications including strictures and refractory ulcerations. A therapy to prevent recurrent BE does not currently exist. Itraconazole with its ability to inhibit important molecular pathways related to BE development could enhance the long-term effectiveness of endoscopic eradication of high-risk BE, thereby promoting a long-term cure Type: Interventional Start Date: Sep 2022 |
CEND-1 in Combination With Neoadjuvant FOLFIRINOX With or Without Panitumumab
Anup Kasi
Colon Cancer
Pancreas Cancer
Digestive Cancer
This is a phase IB/IIA trial to ensure the safety of CEND-1 in combination with with
Folfirinox with or without Panitumumab for treatment of pancreatic, colon and appendiceal
cancers
expand
This is a phase IB/IIA trial to ensure the safety of CEND-1 in combination with with Folfirinox with or without Panitumumab for treatment of pancreatic, colon and appendiceal cancers Type: Interventional Start Date: Oct 2021 |
Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosis
University of Kansas Medical Center
ALS
The purpose of this research study is to evaluate the safety and effectiveness of Ranolazine,
and how well it is tolerated in patients with Amyotrophic Lateral Sclerosis (ALS). Ranolazine
is an FDA approved drug that is used for decreasing chest pain.
expand
The purpose of this research study is to evaluate the safety and effectiveness of Ranolazine, and how well it is tolerated in patients with Amyotrophic Lateral Sclerosis (ALS). Ranolazine is an FDA approved drug that is used for decreasing chest pain. Type: Interventional Start Date: Jun 2018 |
- Previous
- Next