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A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With...
Iovance Biotherapeutics, Inc.
Unresectable Melanoma
Metastatic Melanoma
Stage III Non-small Cell Lung Cancer
Stage IV Non-small Cell Lung Cancer
This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult
participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer
(NSCLC).
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This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma or advanced non-small-cell lung cancer (NSCLC). Type: Interventional Start Date: Jul 2022 |
Personalized Therapy Study - Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
Medtronic
Ventricular Tachycardia
Medtronic is sponsoring the Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS)
to further confirm safety and effectiveness of ventricular iATP therapy in routine clinical
practice, following commercial release of iATP-capable devices.
The iATP PAS is conducted... expand
Medtronic is sponsoring the Intrinsic Antitachycardia Pacing Post-Approval Study (iATP PAS) to further confirm safety and effectiveness of ventricular iATP therapy in routine clinical practice, following commercial release of iATP-capable devices. The iATP PAS is conducted within Medtronic's Product Surveillance Registry platform (NCT01524276). Type: Observational [Patient Registry] Start Date: Aug 2020 |
Social Support and Stress Reduction for Caregivers of Young Adults With IDD
University of Kansas Medical Center
Burden, Caregiver
The objective of this study is to evaluate the feasibility and stress reduction impacts of a
yoga and support group intervention on caregivers of individuals with intellectual and
developmental disabilities.
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The objective of this study is to evaluate the feasibility and stress reduction impacts of a yoga and support group intervention on caregivers of individuals with intellectual and developmental disabilities. Type: Interventional Start Date: Mar 2023 |
Blueberry Intervention Study for Brain Aging
University of Kansas Medical Center
Brain Aging
The purpose of this study is to determine if increased blueberry intake helps increase brain
antioxidant (glutathione) and cerebral blood flow in older adults.
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The purpose of this study is to determine if increased blueberry intake helps increase brain antioxidant (glutathione) and cerebral blood flow in older adults. Type: Interventional Start Date: Jun 2022 |
A Behavioral Activation Intervention Administered in a College Freshman Orientation Course
University of Kansas
Alcohol; Use, Problem
Stress
Binge Eating
Depression
The transition from high school to college is a developmentally sensitive period that is high
risk for escalations in alcohol use. Although risky drinking is a common problem among
freshmen, engagement in treatment services is very low. The proposed study will test a
behavioral... expand
The transition from high school to college is a developmentally sensitive period that is high risk for escalations in alcohol use. Although risky drinking is a common problem among freshmen, engagement in treatment services is very low. The proposed study will test a behavioral activation intervention that addresses factors limiting participation in standard treatment services by targeting alcohol use indirectly, by directly addressing concerns most relevant to incoming college freshmen, and by integrating an intervention into the college curriculum. Type: Interventional Start Date: Sep 2019 |
Quantify the Degree of Pain Relief of Pelvic Congestion Syndrome Following Gonadal Vein Embolization
University of Kansas Medical Center
Pelvic Congestive Syndrome
Pelvic Pain
The primary objective is to quantify the degree of pain relief in patients undergoing gonadal
vein embolization with coils as well as identify clinical or imaging factors that are
predictive of a positive response to treatment, or poor response to treatment.
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The primary objective is to quantify the degree of pain relief in patients undergoing gonadal vein embolization with coils as well as identify clinical or imaging factors that are predictive of a positive response to treatment, or poor response to treatment. Type: Observational Start Date: May 2019 |
Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by...
ECOG-ACRIN Cancer Research Group
ALK Gene Rearrangement
ALK Gene Translocation
ALK Positive
Stage IB Non-Small Cell Lung Carcinoma AJCC v7
Stage II Non-Small Cell Lung Cancer AJCC v7
This randomized phase III trial studies how well crizotinib works in treating patients with
stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation
in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make... expand
This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important for tumor cell growth and progression. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working. Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation. Type: Interventional Start Date: Mar 2015 |
Intermittent Fasting for the Treatment of Type 2 Diabetes Mellitus
University of Kansas Medical Center
Type 2 Diabetes
To test whether a lifestyle program featuring one of two forms of intermittent fasting (IER
or TRE) can feasibly and effectively improve glycemia in patients with type 2 diabetes, and
potentially induce diabetes remission.
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To test whether a lifestyle program featuring one of two forms of intermittent fasting (IER or TRE) can feasibly and effectively improve glycemia in patients with type 2 diabetes, and potentially induce diabetes remission. Type: Interventional Start Date: Jan 2023 |
Effects of Metformin on Airway Ion Channel Dysfunction in Cystic Fibrosis-related Diabetes
University of Kansas Medical Center
Cystic Fibrosis-related Diabetes
Cystic Fibrosis
The purpose of this study is to assess the efficacy of metformin to improve airway ion
channel function in those with CF-related diabetes (CFRD)
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The purpose of this study is to assess the efficacy of metformin to improve airway ion channel function in those with CF-related diabetes (CFRD) Type: Interventional Start Date: Feb 2022 |
Effect of Losartan in Cystic Fibrosis (CF)-NIH Grant #133240
University of Kansas Medical Center
Cystic Fibrosis
The goal of this study is to execute a small clinical proof of concept trial: To examine the
effects of losartan on mucociliary clearance (MCC) in patients not eligible for CFTR rescue
therapies
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The goal of this study is to execute a small clinical proof of concept trial: To examine the effects of losartan on mucociliary clearance (MCC) in patients not eligible for CFTR rescue therapies Type: Interventional Start Date: Feb 2022 |
Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer
SWOG Cancer Research Network
Lung Non-Small Cell Carcinoma
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Stage IVA Lung Cancer AJCC v8
Stage IVB Lung Cancer AJCC v8
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or
without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small
cell lung cancer that is stage IV or has not responded to previous RET directed therapy.
Chemotherapy... expand
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving selpercatinib in combination with carboplatin and pemetrexed may help lower the chance of the cancer growing and spreading. Type: Interventional Start Date: Jul 2022 |
Protocol for Women at Increased Risk of Developing Breast Cancer
Carol Fabian, MD
Breast Cancer
The overall goal of this project is to develop an integrative system of breast cancer risk
assessment based on epidemiologic and biologic risk variables, as well as to develop or
refine risk biomarkers which may be useful in predicting and monitoring response to
prevention... expand
The overall goal of this project is to develop an integrative system of breast cancer risk assessment based on epidemiologic and biologic risk variables, as well as to develop or refine risk biomarkers which may be useful in predicting and monitoring response to prevention interventions. Type: Observational Start Date: Aug 1989 |
Creatine to Augment Bioenergetics in Alzheimer's
University of Kansas Medical Center
Alzheimer's Disease
By doing this study, researchers hope to see if creatine monohydrate is a helpful treatment
for people with Alzheimer's disease.
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By doing this study, researchers hope to see if creatine monohydrate is a helpful treatment for people with Alzheimer's disease. Type: Interventional Start Date: Dec 2022 |
COVID-19 Testing and Vaccine Literacy for Women With Criminal Legal System Involvement
University of Kansas Medical Center
COVID-19 Pandemic
The objective of this research is to use a localized mHealth intervention to boost COVID-19
testing and vaccine literacy, access, and uptake among women with CLSI
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The objective of this research is to use a localized mHealth intervention to boost COVID-19 testing and vaccine literacy, access, and uptake among women with CLSI Type: Interventional Start Date: Mar 2022 |
Early Feasibility Study - Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
The purpose of this study is to evaluate initial clinical safety, device functionality and
effectiveness of the Edwards Transcatheter Atrial Shunt System.
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The purpose of this study is to evaluate initial clinical safety, device functionality and effectiveness of the Edwards Transcatheter Atrial Shunt System. Type: Interventional Start Date: Jul 2018 |
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
University of Kansas Medical Center
Healthy Aging
Alzheimer Disease
The overall goal is to characterize the acute exercise response as it relates to brain
glucose metabolism in aging and Alzheimer's Disease (AD). The study team will also examine
lactate metabolism, relationships with cognition, and the effect of exercise intensity.
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The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD). The study team will also examine lactate metabolism, relationships with cognition, and the effect of exercise intensity. Type: Interventional Start Date: Aug 2020 |
User-friendliness of a Portable Driving Simulator
University of Kansas Medical Center
Parkinson Disease
Multiple Sclerosis
Stroke
The use of simulators to retrain driving skills of patients with stroke, Parkinson's disease
(PD), or multiple sclerosis (MS) is very limited because of cost, space required, and
incidence of simulator sickness in high fidelity simulators. The Principal investigator
recently... expand
The use of simulators to retrain driving skills of patients with stroke, Parkinson's disease (PD), or multiple sclerosis (MS) is very limited because of cost, space required, and incidence of simulator sickness in high fidelity simulators. The Principal investigator recently developed a low cost low fidelity portable driving simulator (PDS). In this pilot study, the study team will (1) determine the ease of use and occurrence of simulator sickness while operating the low fidelity PDS in a clinic setting and (2) the efficacy of the low fidelity PDS to reproduce the benefits from retraining impaired driving skills of stroke survivors in a high-fidelity simulator. Participants: 30 participants, separated according to neurological condition including stroke, PD, or MS, will be randomly allocated to either the PDS or fixed-base high-fidelity simulator training. Each participant will undergo a pre-training evaluation, five hours of designated training and a post-training assessment, similar to the pre-training evaluation. Data will be analyzed according to study aims. The investigators hypothesize that the simple set up of the PDS will make it easier to use and better decrease the incidence of simulator sickness that typically leads to stopping therapy than the high-fidelity simulator. The investigators hypothesize that improvements in lane maintenance, adherence to speed limits, reaction to traffic lights, and overall reaction time after training using the PDS will not be significantly different from improvements observed after training using the high-fidelity driving simulator. Type: Interventional Start Date: Aug 2019 |
HoLEP Prior to Radiation Therapy for Patients With LUTS/Retention and Concurrent Prostate Cancer
University of Kansas Medical Center
Prostate Cancer
Lower Urinary Tract Symptoms
To determine if holmium laser enucleation of the prostate (HoLEP) for the treatment of lower
urinary tract symptoms (LUTS) and/or urinary retention alters the treatment course for
patients concurrently diagnosed with prostate cancer.
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To determine if holmium laser enucleation of the prostate (HoLEP) for the treatment of lower urinary tract symptoms (LUTS) and/or urinary retention alters the treatment course for patients concurrently diagnosed with prostate cancer. Type: Interventional Start Date: Sep 2019 |
HIFT for People With Mobility-Related Disabilities
University of Kansas
Mobility Limitation
Physical Disability
Investigators will examine the feasibility and health outcomes following a high-intensity
functional training intervention for people with mobility-related disabilities. In addition
to participant recruitment, attritions rates, and satisfaction, investigators will assess
changes... expand
Investigators will examine the feasibility and health outcomes following a high-intensity functional training intervention for people with mobility-related disabilities. In addition to participant recruitment, attritions rates, and satisfaction, investigators will assess changes to both physical health outcomes (e.g., strength, body composition) and psychosocial outcomes (e.g., quality of life). The findings will provide evidence for the efficacy of HIFT to improve various health outcomes for a population that experiences health disparities in access to, and engagement in, community-based exercise. Type: Interventional Start Date: Sep 2022 |
Mitigating the Pro-inflammatory Phenotype of Obesity
University of Kansas Medical Center
Blood Pressure
Diabetes
Obesity
Insulin Resistance
Diuretics Drug Reactions
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve
activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating
blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α,... expand
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral clonidine) compared with a BP-lowering control condition (diuretic, hydrochlorothiazide) or a placebo. Type: Interventional Start Date: Jul 2021 |
Exploring Predictors of Response to a Peer-Mediated Intervention for Preschoolers With ASD
University of Kansas Medical Center
Autism Spectrum Disorder
Nonverbal Communication
This study will examine what child variables (i.e., social attention and peer interest)
predict communication gains in response to a peer-mediated intervention for 40
minimally-verbal preschool children with ASD and 80 peers. The Stay-Play-Talk with iPad
intervention will... expand
This study will examine what child variables (i.e., social attention and peer interest) predict communication gains in response to a peer-mediated intervention for 40 minimally-verbal preschool children with ASD and 80 peers. The Stay-Play-Talk with iPad intervention will be implemented for 8 weeks. Gains in communication and reciprocity with peers will be measured at post-treatment and in non-treatment settings. Another goal is to determine if variance in communication gains accounted for by the two social variables differs based on the pre-treatment measurement context. Type: Interventional Start Date: Sep 2021 |
Reversing Glucose and Lipid-mediated Vascular Dysfunction
University of Kansas Medical Center
Blood Pressure
Hypertension
The purpose of our study is to understand the extent to which the blood vessels are affected
by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels
contribute to the development of high blood pressure.
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The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure. Type: Interventional Start Date: May 2022 |
Pulmonary Hypertension Biorepository and Registry
University of Kansas Medical Center
Pulmonary Hypertension
Pulmonary Arterial Hypertension
Pulmonary Hypertension Due to Left Heart Disease
Pulmonary Hypertension, Primary
Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Establish a pulmonary hypertension registry and biorepository to lead towards a further
understanding of the disease.
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Establish a pulmonary hypertension registry and biorepository to lead towards a further understanding of the disease. Type: Observational [Patient Registry] Start Date: Aug 2020 |
Epidural Spinal Cord Stimulation for Hypertension in Patients With Neuropathic Pain
University of Kansas Medical Center
Chronic Pain
Hypertension
Implanted Stimulation Electrodes
The purpose of the ESCAPE Study is to determine the extent to which epidural spinal cord
stimulation (SCS) reduces arterial blood pressure (BP) in patients which chronic low back
pain and hypertension. We also aim to determine the extent to which higher baseline BP (i.e.,... expand
The purpose of the ESCAPE Study is to determine the extent to which epidural spinal cord stimulation (SCS) reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension. We also aim to determine the extent to which higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS implant. This is an observational study of patients undergoing an implantation of a SCS device. Type: Observational [Patient Registry] Start Date: Nov 2020 |
Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly...
Arog Pharmaceuticals, Inc.
Newly Diagnosed FLT3 Mutated AML
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with
that of midostaurin when administered following induction chemotherapy, consolidation
chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3
mutation.... expand
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treatment (arm B). Potentially eligible subjects will be registered and tested for the presence of FLT3 mutation. Once the FLT3 mutation status is confirmed and additional eligibility is established, subject will be randomized and enter into the treatment phase. Type: Interventional Start Date: Aug 2018 |
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