University of Kansas Medical Center

Conditions

• Cardiotoxicity
• HER2/Neu Positive
• Metastatic Malignant Neoplasm in the Brain
• Recurrent Breast Carcinoma
• Stage IV Breast Cancer AJCC v6 and v7

Eligibility

Eligible Ages

Over 18 Years

Eligible Sex

All

Accepts Healthy Volunteers

No

Criteria

Inclusion Criteria:

- STEP 1 REGISTRATION

Patients must:

1. Have metastatic breast cancer, AND

2. Be initiating within 11 calendar days of Step 1 Registration OR be continuing
trastuzumab-based HER-2 targeted therapy without concurrent anthracyclines, AND

3. Be receiving the trastuzumab-based HER-2 targeted therapy for metastatic disease in
first, second, third-, or fourth-line setting. Patients may have brain metastasis.
There is no limit for number of doses of HER-2 targeted therapy prior to
registration.

Examples of eligible HER-2 targeted therapy:

- Trastuzumab or a trastuzumab biosimilar

- Trastuzumab + chemotherapy or hormonal therapy

- Trastuzumab + other HER-2 targeted agent with or without chemotherapy (such as
pertuzumab, lapatinib, and tucatinib)

- Ado-trastuzumab (Kadcyla®)

- Fam-trastuzumab deruxtecan (Enhertu) NOTE: Patients on lapatinib without trastuzumab
are not eligible. Planned treatment with concurrent HER-2 targeted therapy and
anthracyclines is not permitted.

- Patients must be at increased risk for cardiotoxicity defined by at least one
of the following:

1. Previous anthracycline exposure OR

2. 1 or more of the following risk factors for heart disease:

- LVEF 50-54% by local ECHO read*

- Age ≥ 65

- BMI ≥ 30 kg/m2

- Current or prior anti-hypertensive therapy

- Diagnosis of coronary artery disease (CAD)

- Diagnosis of diabetes mellitus

- Diagnosis of atrial fibrillation/flutter Note: ECHO can be performed
at any time prior to registration with the most recent being sent.

- Patients must not have taken within 21 days prior to Step 1 Registration, be
currently taking at the time of Step 1 Registration or planning to take once
registered to Step 1 a beta blocker, ARB, or ACE inhibitor, in order to be
randomized (Arms 1 and 2).

Patients enrolling in the observational cohort (Arm 3) must be currently taking a beta
blocker, ARB, or ACE inhibitor at the time of Step 1 Registration.

- Patients must have a Zubrod Performance status of 0-2

- Patients must have a complete physical examination and medical history within 28
days prior to registration

- Patients must have LVEF >= 50% echocardiogram (2D or 3D) within 28 days prior to
registration. The echocardiogram must be obtained from a S1501 validated ECHO
laboratory (lab) and submitted for central review by the S1501 ECHO core lab.

If a 3D echocardiogram is performed at baseline, sites must ensure that standard 2D
images, including 40chamber and 2-chamber views, are also obtained and submitted at
subsequent timepoints.

All follow-up echocardiograms (every 12 weeks) must be performed using 2D imaging to
allow for standardized assessments. Follow-up scans must be completed at a site that can
provide 2D images per protocol requirements. The echocardiograms cannot be submitted for
central read until after Step 1 registration is complete.

- Patients must have adequate hepatic function as evidenced by all of the following
within 28 days prior to registration:

- Serum bilirubin < 3.0 x institutional upper limit of normal (IULN)

- Serum glutamic oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST)
and serum glutamic pyruvic transaminase (SGPT)/alanine aminotransferase (ALT) <
5.0 x IULN

- Patients must not be dialysis dependent

- No other prior malignancy is allowed except for the following: adequately treated
basal cell or squamous cell skin cancer, in situ cervical cancer, prostate cancer on
active surveillance, adequately treated stage I or II cancer from which the patient
is currently in complete remission, or any other cancer from which the patient has
been disease free for five years

- Patients must not be pregnant or nursing due to potential fetal or nursing infant
harm; women/men of reproductive potential must have agreed to use an effective
contraceptive method, a woman is considered to be of "reproductive potential" if she
has had menses at any time in the preceding 12 consecutive months; in addition to
routine contraceptive methods, "effective contraception" also includes heterosexual
celibacy and surgery intended to prevent pregnancy (or with a side-effect of
pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral
tubal ligation; however, if at any point a previously celibate patient chooses to
become heterosexually active during the time period for use of contraceptive
measures outlined in the protocol, he/she is responsible for beginning contraceptive
measures

- Patients must be willing to submit blood specimens

- Sites must seek additional patient consent for the future use of specimens

- Patients must be informed of the investigational nature of this study and must sign
and give written informed consent in accordance with institutional and federal
guidelines

- For participants with impaired decision-making capabilities, legally authorized
representatives may sign and give informed consent on behalf of study participants
in accordance with applicable federal, local, and CIRB regulations.

- As a part of the OPEN registration process the treating institution's identity is
provided in order to ensure that the current (within 365 days) date of institutional
review board approval for this study has been entered in the system

- STEP 2 REGISTRATION (Randomization)

- Patients must not be registered to step 2 until confirming via RAVE EDC that the
patient's LVEF by echocardiogram was >= 50% by central review. Patients must be
registered within 21 calendar days of submission of the ECHO study/

- Site must verify that there is no known change in the step 1 eligibility since
initial registration

Recruiting Locations

Study Contact

Detailed Description

PRIMARY OBJECTIVES: I. To estimate the 2-year cumulative incidence of cardiac dysfunction and/or predefined cardiac events in patients with metastatic breast cancer receiving trastuzumab-based HER-2 targeted therapy and beta blockers, angiotensin receptor blocker (ARB), or angiotensin converting enzyme (ACE) inhibitor. II. To develop a model including clinical factors and potential biomarkers to predict risk of cardiac dysfunction and/or predefined cardiac events in patients with metastatic breast cancer receiving trastuzumab-based HER-2 targeted therapy and beta blockers, angiotensin receptor blocker (ARB), or angiotensin converting enzyme (ACE) inhibitor. SECONDARY OBJECTIVES: I. To assess whether prophylactic beta blocker therapy with carvedilol compared with no prophylaxis reduces the risk of cardiac dysfunction and/or predefined cardiac events in patients with metastatic breast cancer receiving trastuzumab-based HER-2 targeted therapy. II. To evaluate if prophylactic carvedilol compared with no prophylaxis results in a longer time to first interruption of trastuzumab-based HER-2 targeted therapy due to either cardiac dysfunction or events. III. To compare the local and central reads of left ventricular ejection fraction (LVEF) and strain and assess if strain changes can predict drop in ejection fraction. IV. Assess if strain can be used in the community as a marker of cardiotoxicity. TERTIARY OBJECTIVES: I. To evaluate the lle655Val and Alall70Pro single nucleotide polymorphisms (SNPs) of the HER-2 gene as a predictive biomarker of study-defined cardiac dysfunction and/or predefined cardiac events. II. To evaluate plasma neuregulin-1 at baseline and over study time as a predictive biomarker of study-defined cardiac dysfunction and/or predefined cardiac events. III. To evaluate the feasibility of local labs performing serial left ventricular strain in an NCTN group setting, with the goal of 75% of patients contributing both a baseline and at least one follow-up strain measurement. IV. To bank blood for future translational medicine studies such as brain natriuretic peptide (BNP), additional SNPs, and high sensitivity troponin. OUTLINE: Patients are randomized to 1 of 2 arms. Patients taking beta blocker, ARB, or ACE inhibitor at registration are assigned to Arm III. ARM I: Patients not taking beta blocker, ARB, or ACE inhibitor at registration receive carvedilol orally (PO) twice daily (BID). Courses repeat every 12 weeks for 108 weeks in the absence of disease progression or unacceptable toxicity. ARM II: Patients not taking beta blocker, ARB, or ACE inhibitor at registration receive no study intervention for up to 108 weeks. ARM III: Patients undergo observation for up to 108 weeks.