Phenotype, Genotype and Biomarkers 2
Purpose
The purpose of this study is to learn more about amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases, including frontotemporal dementia (FTD), primary lateral sclerosis (PLS), hereditary spastic paraplegia (HSP), progressive muscular atrophy (PMA) and multisystem proteinopathy (MSP). More precisely, the investigator wants to identify the links that exist between the disease phenotype (phenotype refers to observable signs and symptoms) and the disease genotype (genotype refers to your genetic information). The investigator also wants to identify biomarkers of ALS and related diseases.
Conditions
- Amyotrophic Lateral Sclerosis
- Hereditary Spastic Paraplegia
- Primary Lateral Sclerosis
- Progressive Muscular Atrophy
- Frontotemporal Dementia
Eligibility
- Eligible Ages
- Over 7 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
for affected individuals (primary participants) include: - Clinical diagnosis or suspicion of ALS or a related disorder, including, but not limited to, ALS-FTD, PLS, HSP, FTD, Multisystem Proteinopathy (MSP) and PMA. - Subject is able and willing to comply with study procedures
Exclusion Criteria
for affected individuals (primary participants) include: - Subjects with a condition or who are in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions Inclusion criteria for biological family members (secondary participants) include: - Family member of an enrolled affected primary participant Exclusion Criteria for biological family members (secondary participants) include: - Subjects with a condition or who are in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Primary participants | Patients that have or are suspected to have ALS or a related neurodegenerative disease | |
| Secondary Participants | Family members of primary participants enrolled in the study |
Recruiting Locations
Kansas City, Kansas 66160
More Details
- Status
- Recruiting
- Sponsor
- University of Miami