Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study

Purpose

This trial evaluates how inhalational anesthesia (drawn in through the lungs) and total intravenous anesthesia (TIVA) (through a needle in a vein in the arm) change the body's ability to recover from surgery or whether they impact the immune system immediately after surgery in patients with colon cancer. It is unknown whether these types of anesthesia change recovery from surgery or change the chances cancer comes back following surgery. This study may help researchers learn how different types of anesthesia affect recovery from colon cancer surgery.

Condition

  • Colon Adenocarcinoma

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Ability of participant OR Legally Authorized Representative (LAR) to understand this study, and participant or LAR willingness to sign a written informed consent - Males and females age >= 18 years on day of consent - Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2 - Patients undergoing resection for biopsy proven colon adenocarcinoma - Medically fit for colon resection - Ability to complete required study questionnaires - Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion Criteria

  • Diagnosis of rectal adenocarcinoma - Simultaneously enrolled in any therapeutic clinical trial. Subsequent enrollment in an adjuvant therapy clinical trial is not automatically prohibited by this trial. Trial eligibility for subsequent studies will be determined by the VIVA principal investigator (PI) and the PI of the other clinical trial in question - Diagnosed with a psychiatric illness or is in a social situation that would limit compliance with study requirements - Active grade 3 (per the National Cancer Institute Common Terminology Criteria for Adverse Events [NCI CTCAE] version 5.0) or higher viral, bacterial, or fungal infection within 2 weeks prior to the first dose of study treatment - Prisoner status - Allergies to eggs, egg products, soybeans, or soy products (relative or absolute contraindication to propofol) - Personal or first degree relative with a history of malignant hyperthermia (absolute contraindication to inhaled volatile anesthetics) - Diagnosis of inflammatory bowel disease - Planned multi-visceral resection (examples include: pelvic exenteration, combined liver and colon resection) - Patients undergoing resection for unresectable polyps, or incomplete polypectomies without biopsy proven adenocarcinoma are excluded

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Outcomes Assessor)
Masking Description
Patients and statisticians are blinded to the type of anesthesia.

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Arm I (sevoflurane, fentanyl citrate, propofol) 		Patients receive SOC sedation with sevoflurane via inhalation and fentanyl IV on study during to SOC surgery. All patients also undergo blood sample collection throughout the study and collection of tissue sample during surgery.
  • Procedure: Biospecimen Collection
    Undergo blood and tissue sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Other: Electronic Health Record Review
    Ancillary studies
  • Drug: Fentanyl Citrate
    Given via injection
    Other names:
    • Actiq
    • Fentanyl
    • Fentyl
    • Oralet
    • Sublimaze
  • Drug: Propofol
    Given IV
    Other names:
    • Diprivan
  • Other: Questionnaire Administration
    Ancillary studies
  • Drug: Sevoflurane
    Given via inhalation
    Other names:
    • Ultane
  • Procedure: Surgical Procedure
    Undergo SOC surgery
    Other names:
    • Operation
    • Surgery
    • Surgery Type
    • Surgery, NOS
    • Surgical
    • Surgical Intervention
    • Surgical Interventions
    • Surgical Procedures
    • Type of Surgery
Experimental
Arm II (fentanyl citrate, propofol) 		Patients receive SOC sedation with fentanyl IV and propofol IV on study during to SOC surgery. Patients also undergo blood sample collection throughout the study and collection of tissue sample during surgery.
  • Procedure: Biospecimen Collection
    Undergo blood and tissue sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Other: Electronic Health Record Review
    Ancillary studies
  • Drug: Fentanyl Citrate
    Given via injection
    Other names:
    • Actiq
    • Fentanyl
    • Fentyl
    • Oralet
    • Sublimaze
  • Drug: Propofol
    Given IV
    Other names:
    • Diprivan
  • Other: Questionnaire Administration
    Ancillary studies
  • Procedure: Surgical Procedure
    Undergo SOC surgery
    Other names:
    • Operation
    • Surgery
    • Surgery Type
    • Surgery, NOS
    • Surgical
    • Surgical Intervention
    • Surgical Interventions
    • Surgical Procedures
    • Type of Surgery

Recruiting Locations

University of Kansas Cancer Center
Kansas City, Kansas 66160
Contact:
Luke V. Selby
913-588-7750
lselby@kumc.edu

More Details

Status
Recruiting
Sponsor
University of Kansas Medical Center

Study Contact

Detailed Description

PRIMARY OBJECTIVE: I. To evaluate the differential impact of TIVA versus inhaled anesthesia on neutrophil extracellular traps (NET) inflammation and immunosuppression among patients undergoing cancer surgery. SECONDARY OBJECTIVES: I. To evaluate the differential impact of TIVA versus inhaled total anesthesia choice on patient reported post-operative recovery: Ia. Overall, and domain-specific post-operative recovery (as measured by the Quality of Recovery Score [QoR]-40) on the day of discharge and other post-operative timepoints; Ib. Changes in overall and domain-specific post-operative recovery over time. II. To evaluate the differential impact of TIVA versus inhaled total anesthesia choice on peri-operative clinical and anesthetic outcomes, as recorded in the electronic medical record (EMR), including: IIa. Post-operative nausea and vomiting (from medical record); IIb. Post-operative pain (measured on a 1-10 scale) (from medical record); IIc. Return of gastrointestinal (GI) function (from medical record); IId. Post-operative cognitive impairment (from medical record); IIe. 30 and 90 days post-operative complications; IIf. Disease-free survival (from medical record); IIg. Overall survival (from medical record). III. To evaluate the differential impact of TIVA versus inhaled total anesthesia choice on circulating levels of inflammatory cytokines, immune cell populations, global inflammatory markers. IV. To evaluate the differential impact of TIVA versus inhaled total anesthesia choice on levels of circulating tumor DNA (ctDNA) at multiple post-operative timepoints according to standard of care practices of the University of Kansas Medical Center (KUMC) Division of Medical Oncology GI oncology practice. V. Correlation of peri-operative clinical and anesthetic outcomes to neutrophil extracellular traps (NET) levels, measures of immune suppression, ctDNA. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive standard of care (SOC) sedation with sevoflurane via inhalation and fentanyl intravenously (IV) on study prior to SOC surgery. Some patients may also receive sedation with propofol IV prior to surgery. All patients also undergo blood sample collection throughout the study and collection of tissue sample during surgery. ARM II: Patients receive SOC sedation with fentanyl IV and propofol IV on study prior to SOC surgery. Patients also undergo blood sample collection throughout the study and collection of tissue sample during surgery. After completion of study treatment, patients are followed up at 1 and 3 days, 3 and 6 weeks, 3 and 6 months, and then yearly for 5 years from SOC surgery.