GLP-1RA Effects on Lean Mass and Bone Health in Midlife Women
Purpose
This study is designed with the interest to learn on the effects of estrogen levels and how it affects body compositions and muscle function in midlife women who are taking a GLP-1RA for weight loss.
Conditions
- Body Composition
- Muscle Function
- GLP-1
- Estrogen Level
Eligibility
- Eligible Ages
- Between 35 Years and 60 Years
- Eligible Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Females - Age 35-60 year - BMI≥30 or BMI≥27 and at least one cardiometabolic risk factor (dyslipidemia, hypertension, obstructive sleep apnea, metabolic syndrome, fatty liver, PCOS) - Newly prescribed a GLP-1RA medication - English speaking - Body weight stable for the past 6 months
Exclusion Criteria
- Pregnant women - Under age 35 or over age 60 - Born male - Cannot consent for themselves - Cannot read and speak in English - Type 2 diabetes - Recently discontinued a GLP-1RA medication (less than 6-months since discontinuing) - Contraindications for taking a GLP-1 RA medication (personal or family history of medullary thyroid carcinoma, personal or family history of multiple endocrine neoplasia type 2, personal history of pancreatitis, pregnancy, hypersensitivity to the drug or any component of the drug, active suicidal ideation) - Currently taking aromatase inhibitors or selective estrogen receptor modulators (SERMs)
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| GLOW Participants | New patients, those who are newly prescribed a GLP-1RA medication will be invited to participate in the study where different measurements will be completed to assess body composition, hormone levels, muscle strength and nutrition. |
Recruiting Locations
The University of Kansas Medical Center
Kansas City, Kansas 66160
Kansas City, Kansas 66160
More Details
- Status
- Recruiting
- Sponsor
- University of Kansas Medical Center