Purpose

The purpose of this study is to understand cognitive impairment in end stage renal disease before and after a kidney transplant.

Condition

Eligibility

Eligible Ages
Between 30 Years and 70 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Pre-transplant ESRD patients between the ages of 30 and 70 years who are listed for renal transplantation - Able to sign pre-transplant consent on their own will - Have english as their native language

Exclusion Criteria

  • Current use of antipsychotics or anti-epileptics - Inability to read or write which will limit their ability to perform the cognitive tests - Claustrophobia or inability to get MRI for other reasons - Unable to sign consent

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
ESRD patients ESRD patients awaiting renal transplantation
  • Procedure: Kidney Transplant
    Kidney Transplant Surgery
Control Arm Subjects without kidney disease

Recruiting Locations

University of Kansas Medical Center
Kansas City, Kansas 66160

More Details

Status
Recruiting
Sponsor
University of Kansas Medical Center

Study Contact

Andrew Jurgensen, BS
913-574-0895
ajurgensen@kumc.edu

Detailed Description

Cognitive impairment is very common in patients with End Stage Renal Disease (ESRD). It exact mechanisms are not clear, but patients with ESRD have more cerebral white matter changes. Several studies have shown that cognitive function improves post-transplant, indicating that there may be some reversibility in the process. This study will examine the correlation between cognitive impairment and structural brain changes before and after renal transplantation. We will also study the correlation of cognitive function with serum inflammatory markers before and after transplant. These results will be compared to aged matched healthy controls without kidney disease.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.