The purpose of this study is to understand cognitive impairment in end stage renal disease before and after a kidney transplant.



Eligible Ages
Between 30 Years and 70 Years
Eligible Genders
Accepts Healthy Volunteers

Inclusion Criteria

  • Pre-transplant ESRD patients between the ages of 30 and 70 years who are listed for renal transplantation - Able to sign pre-transplant consent on their own will - Have english as their native language

Exclusion Criteria

  • Current use of antipsychotics or anti-epileptics - Inability to read or write which will limit their ability to perform the cognitive tests - Claustrophobia or inability to get MRI for other reasons - Unable to sign consent

Study Design

Study Type
Observational Model
Time Perspective

Arm Groups

ArmDescriptionAssigned Intervention
ESRD patients ESRD patients awaiting renal transplantation
  • Procedure: Kidney Transplant
    Kidney Transplant Surgery
Control Arm Subjects without kidney disease

Recruiting Locations

University of Kansas Medical Center
Kansas City, Kansas 66160

More Details

University of Kansas Medical Center

Study Contact

Andrew Jurgensen, BS

Detailed Description

Cognitive impairment is very common in patients with End Stage Renal Disease (ESRD). It exact mechanisms are not clear, but patients with ESRD have more cerebral white matter changes. Several studies have shown that cognitive function improves post-transplant, indicating that there may be some reversibility in the process. This study will examine the correlation between cognitive impairment and structural brain changes before and after renal transplantation. We will also study the correlation of cognitive function with serum inflammatory markers before and after transplant. These results will be compared to aged matched healthy controls without kidney disease.


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