Print

Purpose

This project is intended to determine the magnitude and duration of RMR changes in patients receiving orthopedic surgery. The result will help to guide postoperative nutrition recommendations in patients receiving orthopedic surgery.

Conditions

Eligibility

Eligible Ages
Over 15 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Any individual over 15 undergoing an orthopedic surgery.

Exclusion Criteria

  • Pregnant female - < 15 years old

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Male 50 male subjects undergoing orthopedic surgery.
  • Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments
    Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.
  • Other: Post-surgical nutrition, hydration, RMR and body composition assessments
    Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.
Female 50 female subjects undergoing orthopedic surgery
  • Other: Pre-surgical nutrition, hydration, RMR, and body composition assessments
    Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.
  • Other: Post-surgical nutrition, hydration, RMR and body composition assessments
    Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.

Recruiting Locations

The University of Kansas Medical Center
Kansas City, Kansas 66160
Contact:
Sharon Bradshaw
sbradshaw2@kumc.edu

More Details

Status
Recruiting
Sponsor
University of Kansas Medical Center

Study Contact

Sharon Bradshaw
913-945-6289
sbradshaw2@kumc.edu

Detailed Description

Surgery produces a catabolic response in the body that shifts metabolism from glucose to fat and protein. Despite no studies examining ACLR, studies of other orthopedic surgeries demonstrate increased postoperative energy expenditure, as well as a shift to beta-oxidation. Additionally, in most patients, these changes reverted to baseline within six weeks, although a subset of patients did not return to baseline until beyond 12 weeks. This project will improve our understanding of magnitude and duration of RMR changes following orthopedic surgery, and the subsequent perioperative dietary suggestions that should be made to improve patient outcomes. Currently, postoperative dietary suggestions are not surgery nor patient specific. Determining how orthopedic surgery effects RMR will help to personalize perioperative treatment, rehabilitation, and recovery. Better understanding the change in RMR following orthopedic surgery and implementing more accurate dietary modifications will help to ensure positive outcomes and control of infection following orthopedic surgery.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.