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Purpose

The goal of this behavioral clinical trial is to learn how to increase physical activity in mid-life adults. Specifically, can guided imagery that includes creating mental pictures increase excitement about working out. Participants will be asked to complete testing at the beginning of the study, following 6-weeks of an in-person exercise program, and 6-weeks after finishing the exercise program. Testing will include an exercise test, MRI, questionnaires, computer tasks, and a blood draw.

Conditions

Eligibility

Eligible Ages
Between 45 Years and 65 Years
Eligible Genders
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • speak English - have access to reliable communication (a telephone or cell phone, computer, etc.) - normal or corrected to normal vision and hearing - ambulatory (without the use of assistive devices) - physically underactive - able to give informed consent - able to exercise continuously on the recumbent stepper exercise device for 4 minutes greater than or equal to 25 watts to demonstrate ability to perform exercise on stepper & no aerobic exercise contraindications or other safety/physical concerns - able to communicate with investigators, follow 2-step command & correctly answer consent comprehension questions - stable blood pressure and statin medication doses for 30 days as these affect vascular health/hemodynamics - willing and able to safely enter magnetic resonance (MR) scanner and attempt the MR scan - willing and able to attempt a blood draw

Exclusion Criteria

  • patients with arrhythmias or acute cardiac events will be excluded due to potential complications with the supervised moderate exercise - at risk for hazard due to magnetic fields due to MR safety concerns - have any neurologic or psychiatric disorder except depression, anxiety (including post-traumatic stress disorder) - have history of seizures or head trauma due to MR data quality

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Factorial Assignment
Intervention Model Description
2 (positive affect imagery vs. neutral) x 2 (episodic future thinking vs. recent thinking)
Primary Purpose
Prevention
Masking
Double (Participant, Investigator)
Masking Description
Primary investigator is masked to intervention assignment. Participants are masked to the intervention - however may be able to figure out intervention based on the guided imagery content

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Episodic Future Thinking (EFT) + Positive Affective Imagery (PAI) 		Assigned guided imagery will be delivered during each exercise session throughout the 6-week exercise program. The guided imagery recordings will be delivered via audio recording during warm-up and cool-down periods during in-lab exercise sessions. The EFT will always be delivered during warm-up and the PAI will always be delivered during cool-down.
  • Behavioral: Episodic Future Thinking
    During the audio recorded guided imagery exercise participants will be asked to think in detail of a future (6 months to a year) where they have made healthy choices regarding physical activity and are physically active.
  • Behavioral: Positive Affective Imagery
    During the audio recorded guided imagery exercise participants will be asked to think in detail about the positive outcomes and sensations associated with an exercise bout.
  • Behavioral: HIIT Exercise Intervention
    The high intensity interval training (HIIT) will be conducted 2 times per week for 6 weeks. The duration of each individual exercise session will last about 45 minutes. After the 5-minute warm-up at 30% peak workload, HIIT will consist of repeated 1-minute high intensity bursts ("on" interval) alternated with 1-minute interval recovery ("off" interval) for 25 minutes. The "on" interval will begin at 80% of peak watts (range: 75%-85%) followed by the "off" interval at 10% of peak watts. The session will end with up to 10 minute cool-down at 20% peak workload.
Experimental
Episodic Future Thinking (EFT) + Neutral Affective Imagery (NAI) 		Assigned guided imagery will be delivered during each exercise session throughout the 6-week exercise program. The guided imagery recordings will be delivered via audio recording during warm-up and cool-down periods during in-lab exercise sessions. The EFT will always be delivered during warm-up and the NAI will always be delivered during cool-down.
  • Behavioral: Episodic Future Thinking
    During the audio recorded guided imagery exercise participants will be asked to think in detail of a future (6 months to a year) where they have made healthy choices regarding physical activity and are physically active.
  • Behavioral: Neutral Affective Imagery
    During the audio recorded guided imagery exercise participants will be asked to think in detail about the physical sensations associated with an exercise bout.
  • Behavioral: HIIT Exercise Intervention
    The high intensity interval training (HIIT) will be conducted 2 times per week for 6 weeks. The duration of each individual exercise session will last about 45 minutes. After the 5-minute warm-up at 30% peak workload, HIIT will consist of repeated 1-minute high intensity bursts ("on" interval) alternated with 1-minute interval recovery ("off" interval) for 25 minutes. The "on" interval will begin at 80% of peak watts (range: 75%-85%) followed by the "off" interval at 10% of peak watts. The session will end with up to 10 minute cool-down at 20% peak workload.
Experimental
Episodic Recent Thinking (ERT) + Positive Affective Imagery (PAI) 		Assigned guided imagery will be delivered during each exercise session throughout the 6-week exercise program. The guided imagery recordings will be delivered via audio recording during warm-up and cool-down periods during in-lab exercise sessions. The ERT will always be delivered during warm-up and the PAI will always be delivered during cool-down.
  • Behavioral: Episodic Recent Thinking
    During the audio recorded guided imagery exercise participants will be asked to think about a routine weekly activity.
  • Behavioral: Positive Affective Imagery
    During the audio recorded guided imagery exercise participants will be asked to think in detail about the positive outcomes and sensations associated with an exercise bout.
  • Behavioral: HIIT Exercise Intervention
    The high intensity interval training (HIIT) will be conducted 2 times per week for 6 weeks. The duration of each individual exercise session will last about 45 minutes. After the 5-minute warm-up at 30% peak workload, HIIT will consist of repeated 1-minute high intensity bursts ("on" interval) alternated with 1-minute interval recovery ("off" interval) for 25 minutes. The "on" interval will begin at 80% of peak watts (range: 75%-85%) followed by the "off" interval at 10% of peak watts. The session will end with up to 10 minute cool-down at 20% peak workload.
Active Comparator
Episodic Recent Thinking (ERT) + Neutral Affective Imagery (NAI) 		Assigned guided imagery will be delivered during each exercise session throughout the 6-week exercise program. The guided imagery recordings will be delivered via audio recording during warm-up and cool-down periods during in-lab exercise sessions. The ERT will always be delivered during warm-up and the NAI will always be delivered during cool-down.
  • Behavioral: Episodic Recent Thinking
    During the audio recorded guided imagery exercise participants will be asked to think about a routine weekly activity.
  • Behavioral: Neutral Affective Imagery
    During the audio recorded guided imagery exercise participants will be asked to think in detail about the physical sensations associated with an exercise bout.
  • Behavioral: HIIT Exercise Intervention
    The high intensity interval training (HIIT) will be conducted 2 times per week for 6 weeks. The duration of each individual exercise session will last about 45 minutes. After the 5-minute warm-up at 30% peak workload, HIIT will consist of repeated 1-minute high intensity bursts ("on" interval) alternated with 1-minute interval recovery ("off" interval) for 25 minutes. The "on" interval will begin at 80% of peak watts (range: 75%-85%) followed by the "off" interval at 10% of peak watts. The session will end with up to 10 minute cool-down at 20% peak workload.

Recruiting Locations

University of Kansas Medical Center
Kansas City, Kansas 66160
Contact:
Morgan Brucks, B.A.
913-588-0173

More Details

Status
Recruiting
Sponsor
University of Kansas Medical Center

Study Contact

Morgan Brucks
(913) 588-0173
mbrucks@kumc.edu

Detailed Description

The proposed project will target regulation and reward systems using guided imagery to increase exercise adherence by increasing positive affect and the evaluation of future rewards among mid-life adults. The investigators will conduct a within subject design in 160 mid-life adults (45-65 years of age) and examine the impact of different components of guided imagery on exercise adherence, regulation systems indexed by delay discounting, positive affect related to exercise, and functional neuroimaging (i.e., connectivity between regulation and reward brain regions). Participants will be asked to complete three assessment appointment periods: 1) baseline, 2) 6-weeks (i.e., end of exercise intervention), and 3) 12-weeks. Each appointment will include assessment of primary outcome measures of delay discounting and exercise positive affect. In addition, baseline and 6-week appointments will include functional magnetic resonance imaging (fMRI) assessments of functional connectivity between reward and regulation regions. Physical activity will be measured at baseline, immediately following the intervention, and 6 weeks following the intervention to explore changes in physical activity across study participation. At the end of the final appointment participants will be debriefed on the goals of the study and asked to provide feedback related to feasibility, the guided imagery experience, and exercise intervention experience to inform future research. In addition, blood draws will be completed at baseline to assess genetic risk for developing Alzheimer's disease (i.e., APOE). If successful, this approach could be used in future studies to increase participation in exercise and adherence to exercise interventions with the goal of promoting brain health and reducing the risk of developing Alzheimer's disease. The design of the proposed clinical trial permits a rigorous evaluation of the role of engaging regulation and reward systems to change immediate and future reward. The exercise intervention will consist of one-on-one high intensity interval training (HIIT) overseen by an exercise specialist twice a week for 6 weeks. Exercise adherence will be monitored as the percentage of the weekly exercise and adherence to the HIIT protocol.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.