Lidocaine Infusion Treatment for Subarachnoid Hemorrhage Headaches
Purpose
The goal of this observational study is to evaluate intravenous lidocaine efficacy and safety in treating headache following non-traumatic subarachnoid hemorrhage. Through this prospective analysis, the investigators hope to: 1. show that intravenous lidocaine infusion causes a clinically significant reduction in pain scores in patients with moderate/severe headache pain following non-traumatic subarachnoid hemorrhage; 2. show that intravenous lidocaine infusion is safe in treating headache following non-traumatic subarachnoid hemorrhage; 3. and report vasospasm prevalence in the cohort. Participants will receive lidocaine infusion as treatment for non-traumatic subarachnoid hemorrhage headache and provide pain scores (on a numeric pain scale) every two hours the patients are awake for a maximum of seven days. Monitoring for vasospasm will occur as part of the patients regular medical care.
Conditions
- Subarachnoid; Hemorrhage, Nontraumatic
- Headache
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Patients > 18 years; - Have a favorable neurological status defined as Hunt and Hess score ≤ 3 (as it accounts for patient awareness); - Can communicate numeric pain scores; - Are diagnosed with non-traumatic subarachnoid hemorrhage
Exclusion Criteria
- The patient is diagnosed with traumatic subarachnoid hemorrhage; - If the patient is < 18 years of age; - If numeric pain scores could not be captured for > 3 days of hospitalization; - If the patient had a prior aneurysm; - Chronic pain not associated with non-traumatic subarachnoid hemorrhage diagnosis; - A disability before the stroke (> 2 on modified Rankin Scale score); - A Hunt and Hess score > 3; - Contraindications to lidocaine (significant cardiac disease, arrhythmia, seizures, previous allergic reaction to lidocaine
Study Design
- Phase
- Study Type
- Observational [Patient Registry]
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Lidocaine infusion | Patients will receive a 100 mg intravenous lidocaine bolus followed by an initial infusion at a rate of 2 mg∙kg -1∙h-1 based on ideal body weight. Lidocaine infusions will continue for a minimum of 1 h post-bolus. If headache numeric pain score decreases at all after initiation of infusion, then the rate will drop to 1 mg∙kg -1∙h-1. If headache numeric pain score starts increasing again, then the rate will return to 2 mg∙kg -1∙h-1, otherwise it will remain at 1 mg∙kg -1∙h-1 for up to 48 h. |
Recruiting Locations
Wichita, Kansas 67214
More Details
- Status
- Recruiting
- Sponsor
- University of Kansas Medical Center