WATER IV Prostate Cancer
Purpose
This is a multicenter, prospective, randomized clinical trial that aims to assess the safety and efficacy of Aquablation Therapy in men with low-risk to intermediate to high-risk localized prostate cancer who are candidates for, or have opted for, prostatectomy. Participants will be randomized to either Aquablation Therapy or radical prostatectomy and followed up to 10 years.
Condition
- Localized Prostate Cancer
Eligibility
- Eligible Ages
- Over 45 Years
- Eligible Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Biological male with age ≥ 45 years at the time of consent 2. Biopsy positive Grade Group 1-3 prostate cancer 3. Are candidates for prostatectomy or, in the case of GG1 disease, have already selected a radical therapy as their treatment. 4. Clinical Stage ≤ T2c 5. PSA ≤ 20 ng/ml 6. Prostate volume ≥25 ml
Exclusion Criteria
- Any prior or current local or systemic treatment for prostate cancer, including but not limited to surgery, radiation therapy (external or brachytherapy), tissue ablation, hormone therapy or chemotherapy. 2. Patients with previous surgical or minimally invasive treatment of benign prostatic hyperplasia within the prior 3 months of study treatment. 3. Evidence of lymph node, bone metastasis, extracapsular extension or seminal vesicle invasion. 4. Patient is unwilling to accept a blood transfusion if required. 5. Any condition or history of illness or surgery that may pose an additional risk to patients undergoing the Aquablation or radical prostatectomy procedure such as: 5a. Medical conditions that preclude the use of anesthesia; 5b. Any condition or history of active rectal inflammatory bowel disease or other factors which might increase the risk of rectal injury (i.e. fistula formation); 5c. Patient is unable to stop anticoagulants or antiplatelet agents prior to study treatment per standard of care; 5d. Any other condition or history of infection, illness or surgery that in the opinion of the investigator might affect the outcome of the study procedure, study conduct, and study results; or pose additional risks to the patient (e.g., other cancer, active urethral stricture disease). 6. Patients who are unable to provide informed consent due to cognitive impairment, legal status (such as incarceration), or other factors limiting autonomy or unwilling or unable to follow study instructions including randomization and complete all required study visits through 10 years. This includes individuals with severe cognitive disabilities, those under legal guardianship, or those currently incarcerated. 7. Patient currently participating in other studies unless approved by Sponsor in writing.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Aquablation Therapy |
The Aquablation Therapy arm will receive Aquablation with either the AQUABEAM Robotic System or HYDROS Robotic System |
|
|
Active Comparator Radical Prostatectomy |
The radical prostatectomy arm will receive the standard of care radical prostatectomy procedure. |
|
Recruiting Locations
University of Kansas Medical Center
Kansas City 4273837, Kansas 4273857 66103
Kansas City 4273837, Kansas 4273857 66103
More Details
- Status
- Recruiting
- Sponsor
- PROCEPT BioRobotics